We offer metabolite profiling and fingerprinting using GC-MS and accurate mass LC-MS/MS. We perform stable isotope labelling, pathway elucidation, quantitative single compound analysis, bioinformatics and contract R&D.
Targeted metabolite profiling
Targeted analysis is used to detect a set of known metabolites, these can be very specifically a subset of metabolites or all known compounds present in our database. Further we differentiate between different chemical classes, lipid, polar or aromatic compounds.
We are currently measuring a wide range of compounds:
- Vitamins
- Carotenoids
- Flavonoids
- Amino acids
- Organic acids
- Sugars
- Fatty acids
- Acyl-Carnitines
- Alkaloids
Comprehensive metabolite profiling
Allows the detection of compounds with known and unknown structure. Thus also making use of all the unidentified peaks in a sample. This can give new leads in metabolic changes in biological samples and could eventually lead to the identification of biomarker or the underlying mechanisms of phenotypes.
Lipidomics
The lipid composition of human samples proofs relevant to understand diseases and mode-of-action of bioactive ingredients (APIs). In plant and microorganisms it is important to study the lipidome to understand cellular processes and bioprocesses.
Energy Metabolite Profiling
Allows the detection of compounds of central metabolism, nucleotides (e.g. ATP/ADP) and reduction equivalents (e.g. NAD, NADP).
Aroma Profiling
The identification of aroma compounds contributing to flavour in natural food products, processed foods and beverages is crucial for success. We help our customers in defining the most important aroma compounds in their products and optimization of those.
Metabolite Fingerprinting
Metabolite Fingerprinting allows the fast discrimination of a set of samples. The technology allows a fast way of looking at metabolic differences and can be used to screen a large set of samples. The identified patterns or clusters can in the next step be further characterized, for example using the profiling platform with a subset of interesting samples.
Stable Isotope Labelling
Tracking and tracing the flux of metabolites is done using stable isotopes, like 2H, 13C or 15N. Our stable isotope toolbox allows us to elucidate pathways and identify sideroutes and byproducts.